The principles of performing employee's prophylactic medical examinations are regulated by the Labor Code and a proper executive deed. There are also other regulations that concern particular groups of workers - like drivers. The range and frequency of medical examination is being established by the doctor performing the examination, based on "Guidelines to workers' prophylactic medical examinations". These guidelines do not concern particular jobs, but are related to occupational exposure to physical, chemical, biological and psychosocial hazards. Driving is a kind of work that requires total psychomotor efficiency. This article presents standards of prophylactic medical examination of drivers who perform commercial "road transport", drivers that do not come under the "road transportation" act, and other persons that make use of their driving qualifications for occupational purposes. Med Pr 2008;59(1):39-47