Background: The aim of this study was to find out the relationship between occupation and health-related quality of life. Material and methods: The study included 504 pregnant women. Two questionnaires, SF-36v2 and EQ-5D, were used to estimate healthrelated quality of life. The information on socio-economic status were gathered by performing the third survey. Results: The study evidenced that the health-related quality of life of working women was significantly better than that of those who were on sick leave or unemployed. In the study group, white collar workers had significantly more childbirths in the past than blue collar workers (p = 0.0055). The mean age of primiparas employed as white collar workers was 28 while the mean age of blue-collar primiparas was 26, and the difference was significant (p = 0.0000). Conclusions: The occupation is important not only because it decides about the economic status, but it also influences the health-related quality of life of pregnant women. Med Pr 2011;62(6):601-607