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Med. Pr. 2004;55(1)

Teratogenic effect of rubber components

Teratogenne działanie niektórych komponentów gumy

Krystyna Sitarek Z Zakładu Toksykologii i Kancerogenezy Instytut Medycyny Pracy im. prof. J. Nofera w Łodzi

Abstract

This study was performed to evaluate the effects of prenatal development of rats were exposed to Polnoks R and its monomer 2,2,4-trimethyl-1,2-dihydroquinoline (TMDHQ) by gavage every day on days 6-15 of gestation at doses equivalent 6%, 13% and 25% of LD50. Polnoks R and TMDHQ administered per os associated with significant maternal toxicity, embryonal lethality, retarded fetal development and congenital defects.
Polnoks R induced skeletal malformations, internal hydrocephalus, and hydronephrosis. 2,2,4-trimethyl-1,2-dihydroquinoline produced internal mal-formations (exencephale, hydrocephalus, anophthalmia, hydronephrosis and renal hypoplasia) and skeletal malformations of ribs and vertebrae.
Polnoks R monomer - 2,2,4-trimethyl-1,2-dihydroquinoline is used as an antioxidant in etastomer and rubber productions.
Polnoks R and its monomer 2,2,4-trimethyl-1,2-dihydroquinoline are teratogenic to rats and induces CNS, kidneys and skeletal defects.

Key words

Polnoks R, 2,2,4-trimethyl-1,2-dihydroquinoline, internal and skeletal malformations, experimental study