EPIDEMIOLOGY UNIT
Head: Prof. Beata Pepłońska, MD, PhD
phone: (+48) 42 631 46 82
e-mail: Beata.Peplonska@imp.lodz.pl
Scope of the activities:
Research:
- Developing protocols, organization and conduction of the epidemiological studies in the area of occupational and environmental epidemiology
- Epidemiological assessment of the association between occupational, environmental and genetic factors and the occurrence of malignant neoplasms.
- Development of information materials and recommendations focusing on the prevention of chronic diseases for employees
Main current research projects carried out in the epidemiology unit are in the field of:
- the etiology of malignant breast cancer including the occupational, environmental and genetic causes
- assessment of the impact of night shift work on the risk factors for breast cancer, including lifestyle factors and hormonal factors,
- assessment of factors affecting mammographic density, in particular cadmium.
International cooperation:
STAMI – The National Institute of Occupational Health in Norway, Oslo
International Agency for Research on Cancer (IARC), Lyon
National Cancer Institute, National Institute of Health (US), Bethesda
ECNIS- Network of Excellence- www.ecnis.org
Research projects:
Polish-Norwegian Research Cooperation Program:
„Night shift work, melatonin metabolism and breast cancer risk factors in nurses” – 2008-2011
Principal Investigator: Beata Pepłońska, MD, PhD,
„Breast Cancer Risk and Epigenetic Effects of the Rotating Night Shift Work and Lifestyle” – 2013-2017
Principal Investigator: Beata Pepłońska, MD, PhD.
National Science Center:
“Investigating causes of breast cancer- correlation between environmental cadmium exposure and mammographic density” - OPUS 9, NZ7 – 2015-2017
Principal Investigator: Beata Pepłońska, MD, PhD,
“Night shift work and the risk of selected malignancies” –KBN, - 2010-2013
Principal Investigator: Beata Pepłońska, MD, PhD.
Statutory projects NIOM:
“Effect of night shift work on diet of nurses”- 2017-2018
Principal Investigator: Beata Pepłońska, MD, PhD,
“Investigating the relationship between work at night and the bone mineral density of women”-2016-2018
Principal Investigator: Agnieszka Bukowska-Damska, PhD.
Major publications:
1. Peplonska B, Bukowska A, Wieczorek E, Przybek M, Zienolddiny S, Reszka E (2017) Rotating night work, lifestyle factors, obesity and promoter methylation in BRCA1 and BRCA2 genes among nurses and midwives. PLoS One 12: e0178792. 10.1371/journal.pone.0178792 [doi];PONE-D-16-51367 [pii].
2. Reszka E, Przybek M, Muurlink O, Peplonska B (2017) Circadian gene variants and breast cancer. Cancer Lett 390: 137-145. S0304-3835(17)30035-6 [pii];10.1016/j.canlet.2017.01.012 [doi].
3. Burton A, Byrnes G, Stone J, (…), Peplonska B, Bukowska A, (…), McCormack VA (2016) Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems. Breast Cancer Res 18: 130. 10.1186/s13058-016-0787-0 [doi];10.1186/s13058-016-0787-0 [pii].
4. Peplonska B, Bukowska A, Lie JA, Gromadzinska J, Zienolddiny S (2016) Night shift work and other determinants of estradiol, testosterone, and dehydroepiandrosterone sulfate among middle-aged nurses and midwives. Scand J Work Environ Health 42: 435-446. 3581 [pii];10.5271/sjweh.3581 [doi].
5. McCormack VA, Burton A, Dos-Santos-Silva I, (…), Peplonska B, Bukowska A, (…), Boyd NF (2016) International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries. Cancer Epidemiol 40: 141-151. S1877-7821(15)00278-7 [pii];10.1016/j.canep.2015.11.015 [doi].
6. Jablonska E, Gromadzinska J, Peplonska B, Fendler W, Reszka E, Krol MB, Wieczorek E, Bukowska A, Gresner P, Galicki M, Zambrano QO, Morawiec Z, Wasowicz W (2015) Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1. BMC Cancer 15: 657. 10.1186/s12885-015-1680-4 [doi];10.1186/s12885-015-1680-4 [pii].
7. Peplonska B, Bukowska A, Sobala W (2015) Association of Rotating Night Shift Work with BMI and Abdominal Obesity among Nurses and Midwives. PLoS One 10: e0133761. 10.1371/journal.pone.0133761 [doi];PONE-D-15-08791 [pii].
8. Bukowska A, Sobala W, Peplonska B (2015) Rotating night shift work, sleep quality, selected lifestyle factors and prolactin concentration in nurses and midwives. Chronobiol Int 32: 318-326. 10.3109/07420528.2014.975353 [doi].
9. Peplonska B, Burdelak W, Krysicka J, Bukowska A, Marcinkiewicz A, Sobala W, Klimecka-Muszynska D, Rybacki M (2014) Night shift work and modifiable lifestyle factors. Int J Occup Med Environ Health 27: 693-706. 10.2478/s13382-014-0298-0 [doi].
10. Peplonska B, Bukowska A, Sobala W (2014) Rotating night shift work and physical activity of nurses and midwives in the cross-sectional study in Lodz, Poland. Chronobiol Int 31: 1152-1159. 10.3109/07420528.2014.957296 [doi].
11. Trabert B, Falk RT, Figueroa JD, Graubard BI, Garcia-Closas M, Lissowska J, Peplonska B, Fox SD, Brinton LA (2014) Urinary bisphenol A-glucuronide and postmenopausal breast cancer in Poland. Cancer Causes Control 25: 1587-1593. 10.1007/s10552-014-0461-8 [doi].
12. Burdelak W, Peplonska B (2013) [Night work and health of nurses and midviwes--a review]. Med Pr 64: 397-418.
13. Faupel-Badger JM, Duggan MA, Sherman ME, Garcia-Closas M, Yang XR, Lissowska J, Brinton LA, Peplonska B, Vonderhaar BK, Figueroa JD (2014) Prolactin receptor expression and breast cancer: relationships with tumor characteristics among pre- and post-menopausal women in a population-based case-control study from Poland. Horm Cancer 5: 42-50. 10.1007/s12672-013-0165-7 [doi].
14. Peplonska B, Burdelak W, Bukowska A, Krysicka J, Konieczko K (2013) Night shift work characteristics and occupational co-exposures in industrial plants in Lodz, Poland. Int J Occup Med Environ Health 26: 522-534. 10.2478/s13382-013-0126-y [doi].
15. Bukowska A, Peplonska B (2013) [Night shift work and prolactin as a breast cancer risk factor]. Med Pr 64: 245-257.
16. Burdelak W, Bukowska A, Krysicka J, Peplonska B (2012) Night work and health status of nurses and midwives. cross-sectional study. Med Pr 63: 517-529.
17. Gromadzinska J, Peplonska B, Sobala W, Reszka E, Wasowicz W, Bukowska A, Lie JA (2013) Relationship between intensity of night shift work and antioxidant status in blood of nurses. Int Arch Occup Environ Health 86: 923-930. 10.1007/s00420-012-0828-7 [doi].
18. Dallal CM, Brinton LA, Matthews CE, Lissowska J, Peplonska B, Hartman TJ, Gierach GL (2012) Accelerometer-based measures of active and sedentary behavior in relation to breast cancer risk. Breast Cancer Res Treat 134: 1279-1290. 10.1007/s10549-012-2129-y [doi].
19. Reszka E, Peplonska B, Wieczorek E, Sobala W, Bukowska A, Gromadzinska J, Lie JA, Kjuus H, Wasowicz W (2013) Circadian gene expression in peripheral blood leukocytes of rotating night shift nurses. Scand J Work Environ Health 39: 187-194. 3303 [pii];10.5271/sjweh.3303 [doi].
20. Peplonska B, Bukowska A, Sobala W, Reszka E, Gromadzinska J, Wasowicz W, Lie JA, Kjuus H, Ursin G (2012) Rotating night shift work and mammographic density. Cancer Epidemiol Biomarkers Prev 21: 1028-1037. 1055-9965.EPI-12-0005 [pii];10.1158/1055-9965.EPI-12-0005 [doi].
21. Reszka E, Peplonska B, Wieczorek E, Sobala W, Bukowska A, Gromadzinska J, Lie JA, Kjuus H, Wasowicz W (2013) Rotating night shift work and polymorphism of genes important for the regulation of circadian rhythm. Scand J Work Environ Health 39: 178-186. 3299 [pii];10.5271/sjweh.3299 [doi].
22. Vachon CM, Scott CG, Fasching PA, (…), Peplonska B, Bukowska A, (…), Dos-Santos-Silva I (2012) Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk. Cancer Epidemiol Biomarkers Prev 21: 1156-1166. 1055-9965.EPI-12-0066 [pii];10.1158/1055-9965.EPI-12-0066 [doi].
23. Peplonska B, Bukowska A, Gromadzinska J, Sobala W, Reszka E, Lie JA, Kjuus H, Wasowicz W (2012) Night shift work characteristics and 6-sulfatoxymelatonin (MT6s) in rotating night shift nurses and midwives. Occup Environ Med 69: 339-346. oemed-2011-100273 [pii];10.1136/oemed-2011-100273 [doi].
24. Brudnowska J, Peplonska B (2011) [Night shift work and cancer risk: a literature review]. Med Pr 62: 323-338.
25. Broeks A, Schmidt MK, Sherman ME, (…), Peplonska B, (…), Garcia-Closas M (2011) Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Hum Mol Genet 20: 3289-3303. ddr228 [pii];10.1093/hmg/ddr228 [doi].
26. Nyante SJ, Faupel-Badger JM, Sherman ME, Pfeiffer RM, Gaudet MM, Falk RT, Andaya AA, Lissowska J, Brinton LA, Peplonska B, Vonderhaar BK, Chanock S, Garcia-Closas M, Figueroa JD (2011) Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland. Breast Cancer Res 13: R42. bcr2864 [pii];10.1186/bcr2864 [doi].
27. Yang XR, Chang-Claude J, Goode EL, (…), Peplonska B, (…), Garcia-Closas M (2011) Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst 103: 250-263. djq526 [pii];10.1093/jnci/djq526 [doi].
28. Stevens RG, Hansen J, Costa G, Haus E, Kauppinen T, Aronson KJ, Castano-Vinyals G, Davis S, Frings-Dresen MH, Fritschi L, Kogevinas M, Kogi K, Lie JA, Lowden A, Peplonska B, Pesch B, Pukkala E, Schernhammer E, Travis RC, Vermeulen R, Zheng T, Cogliano V, Straif K (2011) Considerations of circadian impact for defining 'shift work' in cancer studies: IARC Working Group Report. Occup Environ Med 68: 154-162. oem.2009.053512 [pii];10.1136/oem.2009.053512 [doi].
29. Faupel-Badger JM, Sherman ME, Garcia-Closas M, Gaudet MM, Falk RT, Andaya A, Pfeiffer RM, Yang XR, Lissowska J, Brinton LA, Peplonska B, Vonderhaar BK, Figueroa JD (2010) Prolactin serum levels and breast cancer: relationships with risk factors and tumour characteristics among pre- and postmenopausal women in a population-based case-control study from Poland. Br J Cancer 103: 1097-1102. 6605844 [pii];10.1038/sj.bjc.6605844 [doi].
30. Peplonska B, Stewart P, Szeszenia-Dabrowska N, Lissowska J, Brinton LA, Gromiec JP, Brzeznicki S, Yang XR, Sherman M, Garcia-Closas M, Blair A (2010) Occupational exposure to organic solvents and breast cancer in women. Occup Environ Med 67: 722-729. oem.2009.046557 [pii];10.1136/oem.2009.046557 [doi].
31. Gaudet MM, Milne RL, Cox A, (…), Peplonska B, (…), Garcia-Closas M (2009) Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev 18: 1610-1616. 18/5/1610 [pii];10.1158/1055-9965.EPI-08-0745 [doi].
32. Ahmed S, Thomas G, Ghoussaini M, (…), Peplonska B, (…), Easton DF (2009) Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet 41: 585-590. ng.354 [pii];10.1038/ng.354 [doi].
33. Garcia-Closas M, Hall P, Nevanlinna H, (…), Peplonska B, (…), Pharoah PD (2008) Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet 4: e1000054. 10.1371/journal.pgen.1000054 [doi].
34. Peplonska B, Lissowska J, Hartman TJ, Szeszenia-Dabrowska N, Blair A, Zatonski W, Sherman ME, Garcia-Closas M, Brinton LA (2008) Adulthood lifetime physical activity and breast cancer. Epidemiology 19: 226-236. 10.1097/EDE.0b013e3181633bfb [doi];00001648-200803000-00011 [pii].
35. Easton DF, Pooley KA, Dunning AM, (…), Peplonska B, (…), Ponder BA (2007) Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447: 1087-1093. nature05887 [pii];10.1038/nature05887 [doi].
36. Brinton LA, Sakoda LC, Lissowska J, Sherman ME, Chatterjee N, Peplonska B, Szeszenia-Dabrowska N, Zatonski W, Garcia-Closas M (2007) Reproductive risk factors for endometrial cancer among Polish women. Br J Cancer 96: 1450-1456. 6603731 [pii];10.1038/sj.bjc.6603731 [doi].
37. de VF, Burstyn I, Straif K, Vermeulen R, Jakobsson K, Nichols L, Peplonska B, Taeger D, Kromhout H (2007) Occupational exposure to NDMA and NMor in the European rubber industry. J Environ Monit 9: 253-259. 10.1039/b615472g [doi].
38. Lissowska J, Gaudet MM, Brinton LA, Peplonska B, Sherman M, Szeszenia-Dabrowska N, Zatonski W, Garcia-Closas M (2008) Intake of fruits, and vegetables in relation to breast cancer risk by hormone receptor status. Breast Cancer Res Treat 107: 113-117. 10.1007/s10549-007-9524-9 [doi].
39. Lissowska J, Gaudet MM, Brinton LA, Chanock SJ, Peplonska B, Welch R, Zatonski W, Szeszenia-Dabrowska N, Park S, Sherman M, Garcia-Closas M (2007) Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analyses. Int J Cancer 120: 2696-2703. 10.1002/ijc.22604 [doi].
40. Cox A, Dunning AM, Garcia-Closas M, (…), Peplonska B, (…), Easton DF (2007) A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet 39: 352-358. ng1981 [pii];10.1038/ng1981 [doi].
41. Peplonska B, Stewart P, Szeszenia-Dabrowska N, Rusiecki J, Garcia-Closas M, Lissowska J, Bardin-Mikolajczak A, Zatonski W, Gromiec J, Brzeznicki S, Brinton LA, Blair A (2007) Occupation and breast cancer risk in Polish women: a population-based case-control study. Am J Ind Med 50: 97-111. 10.1002/ajim.20420 [doi].
42. Anderson WF, Matsuno RK, Sherman ME, Lissowska J, Gail MH, Brinton LA, Yang XR, Peplonska B, Chen BE, Rosenberg PS, Chatterjee N, Szeszenia-Dabrowska N, Bardin-Mikolajczak A, Zatonski W, Devesa SS, Garcia-Closas M (2007) Estimating age-specific breast cancer risks: a descriptive tool to identify age interactions. Cancer Causes Control 18: 439-447. 10.1007/s10552-006-0092-9 [doi].
43. Park SK, Garcia-Closas M, Lissowska J, Sherman ME, McGlynn KA, Peplonska B, Bardin-Mikolajczak A, Zatonski W, Szeszenia-Dabrowska N, Brinton LA (2006) Intrauterine environment and breast cancer risk in a population-based case-control study in Poland. Int J Cancer 119: 2136-2141. 10.1002/ijc.21974 [doi].
44. Garcia-Closas M, Brinton LA, Lissowska J, Chatterjee N, Peplonska B, Anderson WF, Szeszenia-Dabrowska N, Bardin-Mikolajczak A, Zatonski W, Blair A, Kalaylioglu Z, Rymkiewicz G, Mazepa-Sikora D, Kordek R, Lukaszek S, Sherman ME (2006) Established breast cancer risk factors by clinically important tumour characteristics. Br J Cancer 95: 123-129. 6603207 [pii];10.1038/sj.bjc.6603207 [doi].
45. Lissowska J, Brinton LA, Zatonski W, Blair A, Bardin-Mikolajczak A, Peplonska B, Sherman ME, Szeszenia-Dabrowska N, Chanock S, Garcia-Closas M (2006) Tobacco smoking, NAT2 acetylation genotype and breast cancer risk. Int J Cancer 119: 1961-1969. 10.1002/ijc.22044 [doi].
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